CCL19-sorted mature dendritic cells have enhanced lymph node migratory capacity and function

No abstract available

An Investigation of Void Fraction in the Stratified/Annular Flow Regions in Smooth, Horizontal Tubes

Refrigerants R134a and R410A have been used for void fraction measurements in smooth horizontal tubes with diameters between 4mm and 7mm. Quality and mass flux were varied from 5% to 90% and 75 kglm2-s to 700 kglm2-s, respectively. Two test loops, one for condensing flows at 35C and the other for evaporating flows at 5C, were used in the investigation. Results show that near the transition from annular to stratified flow void fraction changed from viscousinertial dependence to gravitational-inertial dominated dependence. An important feature observed is the annular flow region's relative insensitivity to mass flux while the border region between annular and stratified flows is characterized by strong mass flux dependence.Air Conditioning and Refrigeration Project 7

Constructing our identities: Identity Expression amongst lesbian women attending university

Issues of marginalisation have been central to studies on lesbian women, and can affect the expression of sexuality. The university is a site that can potentially provide a physical and relational space that facilitates the negotiation of identities within the context of institutional policies that protect LGBTI people. This article examines data collected from 3 focus group discussions with 11 lesbian women attending university. Using queer theory, this article explores how policy shifts have affected identity expression; identification with ‘categories’ of lesbianism; the intersections of sexual identity with other social markers; and the interplay of space and identity expression. The results of the study indicated new emerging ways of viewing and expressing lesbian identity. The intersection of identity with policies, Westernisation, privilege, and power, as well as an increase in LGBTI consciousness and access to information, has allowed for wider expressions of sexuality that attempt to break gender binaries

PCN162 The Cost-Effectiveness of Second-Line Crizotinib in Eml4-Alk Rearranged Advanced Non-Small Cell Lung Cancer

Background: Snoring / sleep apnea are potentially life threatening breathing occurs during sleep. Little attention is being giving to this clinical condition. Objective: To determine the prevalence of snoring and risk factors associated with obstructive sleep apnea (OSA) among adults workers in two local governments of state, Nigeria Methodology: A cross - sectional survey of 121 young adult and adults working in two local governments of Ekiti state, south western Nigeria was carried out. A self administered questionnaire that was incorporated with Epworth Sleepiness Scale and Berlin Score was used to collect data on socio-demographic characteristics, information related to snoring, sleep related problems and their anthropometric. The Body Mass Index (BMI) and blood pressure of each participant were also measured. Results: Snoring was reported in forty nine (40.5%) of the participants. Their age ranges from 23 to 65 years, mean of 43.89 ± 8.53 SD. The proportion of males and Berlin score (high risk) were significantly (p < 0.001) higher among snores than non regression found sex (OR=7.791, 95% CI =2.971- 20.429), Berlin Score (high risk) (OR= 8.642, 95% CI= 3.159 - 23.639) as significant (P< 0.001) independent risk factors for OSA. Excessive day time sleepiness as determined by ESS score of the participants. Conclusion: The overall prevalence of snoring in this study was 40.5%. Snoring was found to increase with age, body mass index, male sex and those with high risk for Berlin score with high risk of developing Obstructive sleep apne

Electronic damping of molecular motion at metal surfaces

A method for the calculation of the damping rate due to electron-hole pair excitation for atomic and molecular motion at metal surfaces is presented. The theoretical basis is provided by Time Dependent Density Functional Theory (TDDFT) in the quasi-static limit and calculations are performed within a standard plane-wave, pseudopotential framework. The artificial periodicity introduced by using a super-cell geometry is removed to derive results for the motion of an isolated atom or molecule, rather than for the coherent motion of an ordered over-layer. The algorithm is implemented in parallel, distributed across both ${\bf k}$ and ${\bf g}$ space, and in a form compatible with the CASTEP code. Test results for the damping of the motion of hydrogen atoms above the Cu(111) surface are presented.Comment: 10 pages, 3 figure

Brain Correlates of Experience-Dependent Changes in Stimulus Discrimination Based on the Amount and Schedule of Exposure

No grant i

Symmetric-Asymmetric transition in mixtures of Bose-Einstein condensates

We propose a new kind of quantum phase transition in phase separated mixtures of Bose-Einstein condensates. In this transition, the distribution of the two components changes from a symmetric to an asymmetric shape. We discuss the nature of the phase transition, the role of interface tension and the phase diagram. The symmetric to asymmetric transition is the simplest quantum phase transition that one can imagine. Careful study of this problem should provide us new insight into this burgeoning field of discovery.Comment: 6 pages, 3 eps figure

Boundary of two mixed Bose-Einstein condensates

The boundary of two mixed Bose-Einstein condensates interacting repulsively was considered in the case of spatial separation at zero temperature. Analytical expressions for density distribution of condensates were obtained by solving two coupled nonlinear Gross-Pitaevskii equations in cases corresponding weak and strong separation. These expressions allow to consider excitation spectrum of a particle confined in the vicinity of the boundary as well as surface waves associated with surface tension.Comment: 6 pages, 3 figures, submitted to Phys.Rev.

Demonstration of sub-luminal propagation of single-cycle terahertz pulses for particle acceleration

The sub-luminal phase velocity of electromagnetic waves in free space is generally unobtainable, being closely linked to forbidden faster than light group velocities. The requirement of sub-luminal phase-velocity in laser-driven particle acceleration schemes imposes a limit on the total acceleration achievable in free space, and necessitates the use of dispersive structures or waveguides for extending the field-particle interaction. We demonstrate a travelling source approach that overcomes the sub-luminal propagation limits. The approach exploits ultrafast optical sources with slow group velocity propagation, and a group-to-phase front conversion through nonlinear optical interaction. The concept is demonstrated with two terahertz generation processes, nonlinear optical rectification and current-surge rectification. We report measurements of longitudinally polarised single-cycle electric fields with phase and group velocity between 0.77c and 1.75c. The ability to scale to multi-megavolt-per-metre field strengths is demonstrated. Our approach paves the way towards the realisation of cheap and compact particle accelerators with femtosecond scale control of particles

The cytoplasmic domain of L-selectin interacts with cytoskeletal proteins via α-actinin: Receptor positioning in microvilli does not require interaction with α-actinin

The leukocyte adhesion molecule L-selectin mediates binding to lymph node high endothelial venules (HEV) and contributes to leukocyte rolling on endothelium at sites of inflammation. Previously, it was shown that truncation of the L-selectin cytoplasmic tail by 11 amino acids abolished binding to lymph node HEV and leukocyte rolling in vivo, but the molecular basis for that observation was not determined. This study examined potential interactions between L-selectin and cytoskeletal proteins. We found that the cytoplasmic domain of L-selectin interacts directly with the cytoplasmic actin-binding protein α-actinin and forms a complex with vinculin and possibly talin. Solid phase binding assays using the full-length L-selectin cytoplasmic domain bound to microtiter wells demonstrated direct, specific, and saturable binding of purified α-actinin to L-selectin (K(d) = 550 nM), but no direct binding of purified talin or vinculin. Interestingly, talin potentiated binding of α-actinin to the L-selectin cytoplasmic domain peptide despite the fact that direct binding of talin to L-selectin could not be measured. Vinculin binding to the L-selectin cytoplasmic domain peptide was detectable only in the presence of α-actinin. L-selectin coprecipitated with a complex of cytoskeletal proteins including α-actinin and vinculin from cells transfected with L-selectin, consistent with the possibility that α-actinin binds directly to L-selectin and that vinculin associates by binding to α-actinin in vivo to link actin filaments to the L-selectin cytoplasmic domain. In contrast, a deletion mutant of L-selectin lacking the COOH-terminal 11 amino acids of the cytoplasmic domain failed to coprecipitate with α-actinin or vinculin. Surprisingly, this mutant L- selectin localized normally to the microvillar projections on the cell surface. These data suggest that the COOH-terminal 11 amino acids of the L- selectin cytoplasmic domain are required for mediating interactions with the actin cytoskeleton via a complex of α-actinin and vinculin, but that this portion of the cytoplasmic domain is not necessary for proper localization of L-selectin on the cell surface. Correct L-selectin receptor positioning is therefore insufficient for leukocyte adhesion mediated by L-selectin, suggesting that this adhesion may also require direct interactions with the cytoskeleton